• br Author contributions br Conflict of interest

  2021-11-11

  

  Author contributions Conflict of interest Acknowledgments We appreciate technical support of the Research Support Center at the Graduate School of Medical Sciences of the Kyushu University. This study was supported by the Uehara Memorial Foundation and a KAKENHI grant from the Ministry of E

• br Introduction br Mitochondrial dysfunction and cancer br

  2021-11-11

  

  Introduction Mitochondrial dysfunction and cancer Lactate and succinate as oncometabolites Intracellular actions of lactate and succinate as tumor promoters Cell-surface receptors for lactate and succinate and their role in cancer GPR109A as the receptor for butyrate and β-hydroxybu

• Ionotropic glutamate receptors GluRs are ligand gated ion ch

  2021-11-11

  

  Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels that mediate information processing at the majority of excitatory synapses in the brain and participate in such physiological processes as learning and memory, development and maintenance of cellular connections, and pain perceptio

• Seizures in turn selectively modulate the

  2021-11-11

  

  Seizures, in turn, selectively modulate the AMD3100 of GalR in the hippocampus. Thus, pilocarpine-induced SE led to a 30% downregulation of GalR2 without affecting GalR1 (personal communication with T. Bartfai, Scripps Research Institute). Therefore, despite the fact that GalR2 could have been a mo

• OCA has recently been approved for the treatment of patients

  2021-11-11

  

  OCA has recently been approved for the treatment of patients with PBC and is under study for diseases such as NASH, PSC and biliary atresia [30], [49]. Up to now, the beneficial effects of OCA have been related to its anti-cholestatic, anti-inflammatory and anti-fibrotic properties. We have here rep

• In early a collaborative effort between the group that

  2021-11-11

  

  In early 2017, a collaborative effort between the group that pioneered the above described evidence of platinum-induced PUFA chemotherapy resistance and a group that has contributed to much of the known molecular pharmacology of FFA4, revealed that the molecular target of 16:4(n-3), which affords ch

• Recently Bristol Myers Squibb and

  2021-11-11

  

  Recently, Bristol-Myers Squibb and Merck reported their GPR40 agonist research focused on the modification of α,β-position of phenylpropionic histone methyltransferase inhibitor derivatives. For example, in recent published patent applications, Bristol-Myers Squibb claimed the pyrrolidine and dihyd

• br Introduction Isoprenoid structures play an essential role

  2021-11-11

  

  Introduction Isoprenoid structures play an essential role in biology and over 30,000 natural products of this class are known (Greenhagen et al., 2003). Like other animals, insects require these compounds for many disparate processes, including electron transport (e.g., ubiquinones), protein glyc

• p0035 br Declarations of interest br Founding information Th

  2021-11-11

  

  Declarations of interest Founding information This work was partially supported by the New Energy and Industrial Technology Development Organization (NEDO) Japan [grant number P03043]; and Grants-in-Aid for Scientific Research [grant number 16H00738 to H.M.] from the Japan Society for the Prom

• According to the implication of the endocannabinoid system i

  2021-11-11

  

  According to the implication of the endocannabinoid system in IBD, we decided in our laboratory to develop selective CB agonists and FAAH inhibitors to treat these diseases. Recently, we described 3-carboxamido-5-aryl-isoxazoles as selective CB agonists. This series of isoxazoles possesses a 2-subst

• br Materials and methods br Results and

  2021-11-11

  

  Materials and methods Results and discussion To analyze the dependence of lysosomal exocytosis on Cu we exposed HeLa tranylcypromine mg to fresh buffer containing normal levels of free Ca (1mM) and measured β-hex levels in the extracellular medium, followed by measuring β-hex content in the t

• Obesity may be associated with allergic diseases including a

  2021-11-11

  

  Obesity may be associated with allergic diseases (including atopy, asthma, and allergic rhinitis) in children.9, 10, 11 Furthermore, body mass index (BMI) may be associated with bronchial hyper-responsiveness.9, 12 Nevertheless, the relationship between histamine skin reactivity and BMI is poorly un

• The inhibitory activities against HDAC and HDAC of title

  2021-11-11

  

  The inhibitory activities against HDAC1 and HDAC6 of title compounds were evaluated in a fluorescent assay using SAHA and ACY-1215 as positive control. The results were displayed in A. Compounds – with linker containing 5–7 carbons showed good inhibitory activities against HDAC6. They also displayed

• yutopar synthesis We found that activator drugs decrease

  2021-11-10

  

  We found that activator drugs decrease NOsGC protein levels in Sf9 cells. This decrease in protein levels is more pronounced for BAY 60–2770 compared to cinaciguat, and more obvious for α1/β1 compared to α2/β1 (see Fig. 2). This led us to hypothesize that the reduction in protein level correlates wi

• br Conclusions In this study we report the genotype frequenc

  2021-11-10

  

  Conclusions In this study, we report the genotype frequencies for GSTT1, GSTP1, and GSTM1 in Jamaican children. The frequency of the null genotypes of GSTT1 and GSTM1 are similar to those of African-Americans in the US. The GSTP1 genotype frequency is closer to that of the African-American popula

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